Journal: Frontiers in Pharmacology
Article Title: SNORA13 antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma
doi: 10.3389/fphar.2025.1564682
Figure Lengend Snippet: SNORA13 is upregulated in CRC. (A) The volcano plot showed the differentially expressed snoRNAs analyzed by the small RNA array in CRC samples. Red and blue dots represent the upregulated and downregulated snoRNAs, respectively (p < 0.05). SNORA13 is highlighted in red text. (B) A Venn diagram of upregulated snoRNAs in COAD and READ datasets from TCGA and CRC tissues from clinical samples, in which only SNORA13 overlapped. (C) The SNORA13 expression in paired COAD tumor and adjacent non-tumor tissues from TCGA database. (D) The SNORA13 expression in paired READ tumor and adjacent non-tumor tissues from TCGA database. Data are shown as mean ± S.D., (C,D) used paired t -test to perform the statistical significance, three biological replicates for each sample were performed, ** p < 0.01.
Article Snippet: The labeled RNA was hybridized onto Arraystar Human small RNA Microarray (8 × 15K, Arraystar) and the array was scanned by an Agilent Scanner G2505C.
Techniques: Expressing